Article 1. Advocacy for Responsible Antibiotic Production and Use
Title – Advocacy for Responsible Antibiotic Production and Use
Authors – Véronique Mondain, Nicolas Retur, Benjamin Bertrand, Florence Lieutier-Colas, Philippe Carenco, Sylvain Diamantis
Abstract – Antibiotic-resistant bacteria have become one of humanity’s major challenges, as evidenced by the UN Call for Action on Antimicrobial Resistance in 2021. Our knowledge of the processes underlying Antibiotic resistance is steadily improving. Beyond the inappropriate use of antimicrobials in human medicine, other causes have been identified, raising ethical questions and requiring an approach to the problem from a “One Health” perspective. Indeed, it is now clear that the two main problems regarding antibiotics are their misuse in the global food industry and their method of production, both leading to the emergence and spread of bacterial resistance.
Journal – Antibiotics (Basel)
Publication – Published online July 20, 2022 (doi: 10.3390/antibiotics11070980)
Article 2. The Production of Antibiotics Must Be Reoriented: Repositioning Old Narrow-Spectrum Antibiotics, Developing New Microbiome-Sparing Antibiotics
Title – The Production of Antibiotics Must Be Reoriented: Repositioning Old Narrow-Spectrum Antibiotics, Developing New Microbiome-Sparing Antibiotics
Auteurs – Sylvain Diamantis, Nicolas Rétur, Benjamin Bertrand, Florence Lieutier Colas, Philippe Carenco, Véronique Mondain, PROMISE – Professional community network on antimicrobial resistance (AMR)iorésistance en France
Abstract – The development of broad-spectrum antibiotics to combat multi-resistant bacteria is an outdated business model. This strategy led to the introduction of highly effective antibiotics, but their widespread use contributed to the emergence of even broader antibiotic resistance. As a strategy to combat antimicrobial resistance, we believe it is appropriate to promote the use of narrow-spectrum antibiotics. This should involve both the repositioning of old antibiotics and the reorientation of research and development towards new narrow-spectrum antibiotics with low ecological impact. These antibiotics could be prescribed for common conditions such as sore throats and cystitis, which account for the bulk of antibiotic use in humans. Narrow-spectrum, targeted, microbiome-sparing antibiotics could help control antibiotic resistance while being economically sustainable. Their development and production should be supported by governments, which would ultimately benefit from reduced health care costs.
Journal – Antibiotics (Basel)
Publication – Published online July 8, 2022 (doi: 10.3390/antibiotics11070924)
