Discover on this page the progress and main results (expected or finalised) of the PROMISE meta-network since its launch in 2021, classified by major theme.
Creation of a One Health community
👥 One Health meta-network to fight against antibiotic resistance in France
PROMISE brings together 78 partners: 25 national networks of professionals and 53 academic actors (including 45 research units and 4 veterinary schools), bringing together professionals and researchers from the three sectors of Man – Animal – Environment.
Good to know – Since the launch of PROMISE in 2021, several similar projects have been launched, notably in the UK and Canada.
🤝 Development and implementation of national collaborative projects
19 joint projects and joint responses to calls for projects have been submitted under PROMISE. 3 are funded via the meta-network and 16 have been submitted to calls for projects. To date, 9 have been accepted and are funded via CFP (including 3 inter-network clinical research studies).
Good to know – The joint PROMISE projects represent €2.3m for French research into antibiotic resistance.
Creation of national thematic networks
🍃 AMR-Env
This French network dedicated to antibiotic resistance in the environment brings together 22 research units and 4 national networks (OZCAR, Graie, PNDB, Water Agencies). Its main objective is to demonstrate the feasibility of a system for monitoring antibiotic resistance in the environment in France. The study is based on the selection of relevant monitoring indicators and the standardisation of sampling and analysis procedures to make the data produced interoperable.
Good to know – All AMR-Env members are committed to harmonising and inter-calibrating their protocols for quantifying these indicators.
💊 AntibioDEAL
This French network dedicated to preclinical research brings together research units working on the development of new anti-infective agents. Its main objective is to bring together stakeholders from different backgrounds and to set up coherent national working groups on the aspect of antimicrobial discovery and their preclinical evaluation to combat antimicrobial resistance.
Good to know – Every year, the ‘AntibioDEAL Days’ bring together around a hundred national experts developing anti-infective agents, from discovery to pre-clinical evaluation.nique.
Strengthening One Health surveillance
📊 Common platform for One Health surveillance data
This unique data visualisation tool for research makes it easier to access, visualise and analyse surveillance data. It brings together and cross-references resistance/consumption, socio-demographic and environmental data from the 3 sectors to pave the way for more integrated monitoring of antimicrobial resistance, highlight new areas for research and produce valuable content (reports, analyses, illustrations, etc.).
Good to know – Open to partners on request, the platform is currently being rolled out and tested.
📈 Assessing the level of collaboration for more One Health surveillance
The semi-quantitative tool ECoSur (Evaluation of Collaborations for Surveillance) was used to evaluate the organisation and operation of collaborations within a multi-component surveillance system. 72 criteria were evaluated to produce simple graphical outputs to determine the strengths and weaknesses of collaborations, all explained in a publication in JAC-Antimicrobial Resistance.
Good to know – Carried out in 2021 before the launch of PROMISE and then in 2024 after 3 years of existence, this study shows a real impact of the meta-network on collaborations, with major progress made on 13 of the 22 output attributes (stagnation on 9 other attributes).
🔎 Cross-sectoral analysis of the links between resistance and antibiotic use in France
A study inspired by the work of European agencies (JIACRA approach) was carried out on antibiotic resistance and use (consumption data) in France, cross-referencing aggregate data from 12 human and animal health surveillance systems.
Good to know – The data has made it possible to characterise E. coli resistance at regional level in all populations (hospital, town, medico-social establishments and animal populations). This work will continue in 2024-2027 as part of the French INTERSECTION project and the European EU-JAMRAI 2 project.
🌱 Common indicators and protocols for quantifying antibiotic resistance in the environment
A feasibility study highlighted an inter-laboratory validation protocol between 5 research units, the definition of a reproducible method (with little deviation from one laboratory to another) and the validation of common indicators, including 6 indicators for monitoring antibiotic resistance in the environment.
Good to know – The 6 indicators selected: E. coli ESBL (culture method); E. coli RNA16S (qPCR, faecal contamination); intI (qPCR, global resistance indicator); aacA4 (qPCR, marker of human contamination) and aadA/aadB (qPCR, marker of animal contamination).
Contribution to public health policy
📘 Interministerial roadmap 2024 – 2034 on antibiotic resistance
Two mentions of PROMISE to achieve the objectives cited in the interministerial roadmap on ‘Preventing and reducing antibiotic resistance, combating antimicrobial resistance’, which is divided into 5 sections, broken down into 17 strategic objectives.
📃 Combating antibiotic resistance: a textbook case for the ‘One Health’ approach
A mention of PROMISE in the October 2023 edition of the Ministry of Ecological Transition’s Théma collection, which is designed to showcase its expertise, analysis, evaluation and research capabilities, and whose aim is to convey the state of the art on priority themes.
📝 Drawing up a list of ‘bacterial/antibiotic family’ pairs of priority interest
A mention of PROMISE in the Anses opinion (collective expertise report) of June 2023 concerning the drawing up of a list of ‘bacterium/antibiotic family’ pairs of priority interest in controlling the spread of antibiotic resistance from animals to humans and proposals for technical measures to support the manager.
Contribution to European initiatives
🇪🇺 EU-JAMRAI 2
5 PROMISE partners are involved in EU-JAMRAI 2 (Joint Action Antimicrobial Resistance and Healthcare-Associated Infections), a joint European action on antimicrobial resistance and healthcare-associated infections, which involves 30 European countries and more than 120 partners.
Good to know – The AMR-Env network initiated by PROMISE is the leader of activities on the monitoring of antibiotic resistance in the environment within EU-JAMRAI 2.
🏞️ EIONET
1 PROMISE partner is involved in the EIONET (European Environment Information and Observation Network), which aims to provide data, information and expertise to assess the state of the environment in Europe and the pressures it is under.
Good to know – The AMR-Env network initiated by PROMISE contributes to the French influence within the EIONET network.
🧫 JPIAMR
3 projects have been submitted by PROMISE partners as part of the JPIAMR (Joint Programming Initiative on Antimicrobial Resistance), a global collaboration platform that engages 29 nations in the fight against antimicrobial resistance as part of a ‘one health’ approach.
Training tools and skills enhancement
🎓 DU (University Diploma) ‘Antibioresistance and the global One Health approach’
Run by the University of Limoges with the support of the University of Tours and the Institut Pasteur, this 100% distance and asynchronous (no connection at a fixed time) professional training course is available for both initial and continuing education. It offers 7 training modules with the participation of 31 lecturers.
Good to know – This DU, created by PROMISE, trained 15 professionals in 2023-2024. 30 professionals are currently registered for 2024-2025.
💻 MOOC (Massive Open Online Course) “Resistance to antibacterial agents”
Offered by the Institut Pasteur and available in French and English, this university-level course is devoted to the origins and consequences of antibiotic resistance, diagnosis, the global epidemiology in humans and animals and the means of prevention and control, from a ‘one health’ perspective.
Good to know – PROMISE participated in the development and co-funding of this MOOC, which attracted 3180+ registrants from 119 different countries.
Communication and awareness-raising tools
📣 Dissemination of information via website, social networks and newsletter
PROMISE provides a website accessible in French and English. PROMISE has a Linkedin page and an X account which highlight relevant information about the sector (news, job offers, etc.). PROMISE offers subscription to a monthly newsletter (40+ issues by 2025) which summarises the main news of the month.
Good to know – In April 2025, the Linkedin page has 1,600+ subscribers, the X account has 200+ subscribers and the newsletter has 420+ subscribers.
🎥 Production of videos on antibiotic resistance and the global One Health approach
4 videos available on Youtube have been produced to raise awareness among the general public on the following topics: ‘Antibiotic resistance: what is it?’ (animation); ‘Antibiotics: what are the risks of misuse?’ (animation); ‘Microbiota: bacteria that do us good‘ (animation); ’What does antibiotic resistance mean to you?‘ (micro-trottoir).
Good to know – These videos were produced in collaboration between PROMISE and ANEPF (Association nationale des étudiants en pharmacie de France).
🖱️ ‘Antibio, ça résiste‘ mini website: everyone involved, everyone active!
PROMISE is working to make an interactive mini-website available to health professionals in the 3 sectors (Human – Animal – Environment). Its aim is to provide a multi-sectoral overview of current knowledge about antibiotic resistance and ways of preventing it, thereby helping everyone to become familiar with the other sectors.
Organisation of community events
👨⚕️ Thematic seminar: ‘One Health approach to antimicrobial resistance: cross-impacts of human-animal-environment practices’
This seminar, co-organised by PROMISE, took place on 15 November 2024 in Paris, at the Ministry for Ecological Transition and Territorial Cohesion. It brought together 120+ participants in face-to-face and remote sessions.
⚕️ Thematic seminar: ‘Between ecological impacts and stock shortages, what choices should be made for tomorrow’s antibiotic therapy?‘
This seminar, co-organised by PROMISE, took place on 14 November 2022 in Paris, at the Ministry of Health and Access to Care. It was attended by 190+ participants, both face-to-face and remotely.
🚰 8th Water & Health Conference ‘Micropollutants linked to healthcare practices and antibiotic resistance: characterisation, impact and reduction’
This conference organised by the Graie, with PROMISE as a major partner, took place on 14 and 15 November 2023 in Villeurbanne. It brought together 110+ participants in face-to-face and distance learning sessions.
Publication of scientific and educational articles
📰 Advocacy for Responsible Antibiotic Production and Use
The paper ‘Advocacy for Responsible Antibiotic Production and Use’ was published on 20 July 2022 in the journal Antibiotics (Basel) by several members under the PROMISE banner.
📰 The Production of Antibiotics Must Be Reoriented
The paper ‘The Production of Antibiotics Must Be Reoriented: Repositioning Old Narrow-Spectrum Antibiotics, Developing New Microbiome-Sparing Antibiotics’ was published on 08 July 2022 in the journal Antibiotics (Basel) by several members under the PROMISE banner.
